C3G may not get worse over time, or progress, in all patients; however, when it does progress, managing signs and symptoms may become more challenging and require more attention from both you and your healthcare team. Over time, your kidneys may have a harder time filtering fluids and waste from the body.
Your healthcare team will monitor how your kidneys are working to help track your condition over time.
How Your Doctor May Follow Your Disease Progression Over Time
Two key measures to monitor the health of your kidneys include estimated glomerular (glow-MER-u-lar) filtration rate or eGFR and proteinuria (PRO-tee-NEW-ree-ah).
eGFR: eGFR is a number calculated by your doctor that reflects how well your kidneys are functioning. eGFR is based on a lab test called serum creatinine (cree-AT-i-nin) as well as your age, body size, and gender and race.
Creatinine is a waste product from muscle that can be measured in your blood. It can increase in people whose kidneys are not working well.
Serum creatinine is measured by a routine blood test. Your doctor may ask you to fast prior to the test or to refrain from eating cooked meat.
Once your doctor has your serum creatinine level, he or she can use a standard calculation to determine eGFR.
eGFR gives your healthcare team the ability to track how well your kidneys are working. Lower eGFR may indicate that the kidneys are not working well.
Proteinuria: Under normal circumstances, the urine should not contain protein. Proteinuria is checked by examining a urine sample to see whether protein is leaking into the urine. If there is protein in your urine, it may indicate that your kidneys are not working well. Your doctor can also follow trends in proteinuria over time.
Healthcare providers classify many diseases as mild, moderate, or severe. For C3G, moderate or severe disease reflects an increasing level of protein in the urine and creatinine in the blood.
Monitoring your eGFR and proteinuria levels can help your care team determine the progression of kidney damage over time and determine appropriate treatment options.
Treatment for C3G
The main goal of treatment in C3G is to slow damage to the kidney over time.
Unfortunately, there are no approved treatments for patients with the disease. Depending upon the progression of the disease, experts may recommend the use of medications called steroids and immunosuppressants to help reduce inflammation and turn down the immune system; however, information is limited on how well these medications work in C3G. It is important to discuss the risk and possible benefits of available medications and the expectations for your treatment plan with your care team.
New treatment options for those affected by C3G are needed. Clinical trials are research studies that are conducted to better understand and treat disease. Clinical trials of new investigational medicines for C3G are now underway.
Learn more about clinical trials.