The complement system is part of your body’s immune system.
It consists of a group of proteins circulating in the body working to protect you from threats like bacteria and viruses.
There are 3 distinct parts (pathways) of the complement system, known as the classical, lectin, and alternative pathways, each with their own roles and responsibilities.
The classical or lectin pathways are turned "on" or "off," as needed. They help the body fight a threat like an infection, either directly, or by recruiting other parts of the immune system.
By contrast, the alternative pathway is always on and helping to deal with potential threats, but the body controls it to keep it running at a healthy level. Loss of control and overactivity of the alternative pathway can damage healthy cells in your body.
This is believed to be the key problem in patients with C3G.
It is important to know how the complement system may be impacting your kidneys and overall health.